Sezary Syndrome Symptoms and Causes - Oren Zarif - Sezary Syndrome

The most common symptom of Sezary syndrome is intractable itching, and it may even be the most disabling. Treatments that reduce the itching are a useful first line of defense against this disease. Biochemical therapies, including immunotherapy and biologic therapies, are the first-line treatments, but chemotherapy is reserved for advanced cases with large lymph nodes and visceral disease. The following are symptoms and causes of Sezary syndrome.

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The presence of skin lesions can cover any part of the body, and lymph nodes may be enlarged or normal. However, under microscopic examination, abnormal cells may be present. A biopsy is not immediately necessary, but may be indicated if the disease has spread to other tissues and organs. Patients may also have secondary skin infections. If these occur, antibiotics and cultures may be prescribed. However, therapy for Sezary syndrome should be initiated only when signs of the disease develop.

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Treatments for Sezary syndrome may include topical and systemic drugs. In some cases, patients may undergo UVB or PUVA phototherapy. Radiotherapy is also an option. Total skin electron beam therapy may be used in combination with radiotherapy to eliminate cancer cells. Although no cure is available for Sezary syndrome, treatment can help ease the symptoms and prolong the patient's quality of life. When treatment options are limited, a combination of medications may be necessary.

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Sezary syndrome is caused by abnormalities in the DNA of cancerous T-cells. The abnormalities do not come from a person's genes but are acquired over a lifetime. People with Sezary syndrome have deletions and duplications of chromosomes 8 and 17. Although genetics are not a known cause of Sezary syndrome, some researchers believe that older age is a risk factor.

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Sezary syndrome is characterized by enlarged lymph nodes, thickened skin on the hands and feet, and disfigured fingernails and toenails. In rare cases, the condition can be accompanied by an outward turn of the lower eyelids. A doctor should be consulted if you experience any of these symptoms. In most cases, however, the disease is treatable through the use of chemotherapy.

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There are several resources for further information about Sezary syndrome. The National Cancer Institute has an information page about the condition, as well as its related diseases. These resources are intended to help physicians and researchers compare symptoms and signs to identify common features. The National Institutes of Health (NIH) also provides information on rare diseases, including Sezary syndrome. Finally, PubMed is a searchable database of medical literature. It lists journal articles that mention Sezary syndrome.

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The symptoms of Sezary syndrome are a sign that you may be suffering from cutaneous T-cell lymphoma. The cancerous cells in the skin are called Sezary cells, and the disease can lead to enlarged lymph nodes and liver. If you experience any of these symptoms, consult a doctor as soon as possible. If the rash is unrelenting, it may be the first sign of Sezary syndrome.

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A genetic test called T-cell receptor gene rearrangement can help diagnose Sezary syndrome. The test identifies whether the patients have a large number of T-cells with a particular T-cell receptor. Although it is hard to cure mycosis fungoides, treatment can help patients live longer and happier lives. This article will highlight some of the available treatments for Sezary syndrome. The treatment of Sezary syndrome depends on the severity of the condition and the type of disease.

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A doctor will likely order a complete blood cell count to check for signs of cancer. A complete blood count counts white and red blood cells, as well as platelets and hemoglobin. In addition, your doctor will likely perform a blood test to check for HIV antibodies. If you have a high level of these antibodies, you are likely to be HIV positive. If the test reveals no cancerous cells, your physician will likely order a biopsy.